Chemical structure of CJC-1295 in a white background.

CJC 1295 is a synthetic growth hormone releasing (GHRH) peptide that is comprised of 30 amino acids. It is recognized as the most effective GHRH used for growth hormone optimization and can be combined (stacked) with other peptides, such as Ipamorelin, for a powerful synergistic effect, and is often included in a HRT program to manage aging, and a TRT program for enhanced performance. CJC 1295 has demonstrated the ability to increase fat loss and bolster muscle mass while enabling the body to more efficiently synthesize protein. In addition to steadily maximizing GH production, CJC 1295 also increases the secretion of insulin-like growth factor 1 (IGF-1). Primarily secreted by the liver, IGF-1 is an anabolic hormone that helps promote human growth throughout the entire body, particularly skeletal muscle. IGF-1 also aids in bone density and kidney filtration. One of the key advantages of CJC 1295 is that it does not increase the production of potentially contraindicated hormones such as prolactin. CJC 1295 is usually administered via subcutaneous injection.

CJC 1295 with DAC vs CJC 1295 without DAC

Drug affinity complex (DAC) is often combined with CJC 1295, enabling the compound to covalently bind with albumin.  This process helps to substantially increase CJC 1295’s extremely brief half-life from approximately 30 minutes to as long as 8 days. Research studies have also shown that DAC can enhance protein synthesis, increase muscle growth and improve bone density. CJC 1295 without DAC is also known as Modified GRF 1-29.

Possible Side Effects of CJC 1295

The use of CJC 1295, when administered by an experienced physician, does not usually cause side effects. Rarely reported side effects have included water retention, headache, low blood sugar, diarrhea, nausea and mild irritation at injection sites.

Other Benefits of CJC 1295

Although the most commonly described benefits of CJC 1295 are enhanced muscle growth, improved bone density, and the ability to lose body fat more efficiently, this synthetic peptide offers the possibility of a host of other health improvements, including:

  • Better sleep
  • Quicker healing from injury due to better cellular regeneration
  • Immune system improvement
  • Improved skin tone
  • Quicker recovery times during exercise