We can thank the tiny pituitary gland for the production of the protein known Human Growth Hormone (HGH). Located just below the brain, the human pituitary creates GH from a complex mix of 191 amino acids, each encoded by DNA sequence. Amino acids are the source of our body’s protein and as such the basic building blocks of the human body. They also supply a great deal of our body’s energy. GH stimulates the growth of all tissues in the body, including bone.
How is Synthesized GH Manufactured?
From 1960 until the early 1980s, the only source of Human Growth Hormone was the brains of human cadavers, thanks to a program instituted by the National Institutes for Health (NIH). This expensive, laborious process was short-circuited in the late 1970s after the discovery that in rare instances hGH was suspected as a causative agent for Creutzfeldt-Jakob disease. The small risk of contracting the disease from hGH was quickly eliminated due to advanced purification techniques.
The Creutzfeldt-Jakob disease scare inspired among scientists and researchers a renewed commitment to develop safe methods to artificially manufacture GH. As more funds flowed to research and development, three methods were developed to utilize recombinant DNA in order to create artificial GH. Below are brief descriptions of these methods:
Inclusion Body Technology - In this process e coli bacteria are used to mass produce recombinant HGH (rHGH) in small bodies within the bacteria. Unfortunately, this technology caused allergic reactions in some individuals.
Protein Secretion - A newest and sophisticated method to mass-produce rHGH, Protein Secretion is more easily purified than Inclusion Body Technology. The rHGH produced from protein secretion is chemically identical to the HGH produced naturally within the body.
The latest and most efficient method to artificially produce HGH is known as:
Mouse cell technology - As the name implies, the HGHr is created via the insertion of DNA into mouse cells. This process carries a higher initial cost than Inclusion Body Technology and Protein Secretion Technology, but requires less manipulation and purification than the other two processes. As is the case with Protein Secretion, Mouse cell technology produces chemically perfect hGH.
Want to Learn More?
If you believe you may suffer from GH Deficiency, please feel free to schedule lab testing and analysis with our physicians at Virility, Inc. You may call (800) 503-4033, if you would like to learn how GH Optimization may benefit you. Already being treated with testosterone replacement therapy? Ask us how we integrate peptides as part of a complete HRT program.